Protease-activated receptors PARs : mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases. Thromb J. The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.
Ahamed J, Ruf W. Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain. Tissue factor enhances protease-activated receptormediated factor VIIa cell proliferative properties. Coagulation factors VIIa and Xa induce cell signaling leading to up-regulation of the egr-1 gene.
Agonist-mediated tissue factor expression in cultured vascular smooth muscle cells. The Journal of clinical investigation. BMC cancer. Cofactoring and dimerization of proteinase-activated receptors.
Pharmacol Rev. Protease-activated receptor-2 modulates protease-activated receptordriven neointimal hyperplasia. Arteriosclerosis, thrombosis, and vascular biology. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Wang Z. Transactivation of epidermal growth factor receptor by G protein-coupled receptors: recent progress, challenges and future research. International journal of molecular sciences.
Wiiger MT, Prydz H. Scientific reports. Shabani M, Hojjat-Farsangi M. Targeting receptor tyrosine kinases using monoclonal antibodies: the most specific tools for targeted-based cancer therapy. Curr Drug Targets. Cooper J, Giancotti FG. Integrin signaling in cancer: mechanotransduction, stemness, epithelial plasticity, and therapeutic resistance. Cancer cell. Linking integrin conformation to function.
Journal of cell science. Cross-talk of integrin alpha3beta1 and tissue factor in cell migration. Molecular biology of the cell. Inhibition of tissue factor signaling suppresses tumor growth. Eph receptor signaling and ephrins. Cold Spring Harb Perspect Biol. Eph receptor signalling: from catalytic to non-catalytic functions. Tissue factor cytoplasmic domain stimulates migration by activation of the GTPase Rac1 and the mitogen-activated protein kinase p A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein J Cell Biol.
Localization of tissue factor in actin-filament-rich membrane areas of epithelial cells. Exp Cell Res. High-level secretion of tissue factor-rich extracellular vesicles from ovarian cancer cells mediated by filamin-A and protease-activated receptors.
Biochim Biophys Acta. Mueller BM, Ruf W. Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis. Deencryption of cellular tissue factor is independent of its cytoplasmic domain.
Biochemical and biophysical research communications. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling. Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development. Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor model. Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody.
Eisenreich A, Rauch U. Regulation and differential role of the tissue factor isoforms in cardiovascular biology. Trends Cardiovasc Med. Vascular miRb controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes. Cardiovasc Diabetol. MicroRNA miR regulates tissue factor expression in breast cancer cells.
Mol Endocrinol. PARP combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression. Basic fibroblast growth factor increases tissue factor expression in circulating monocytes and in vascular wall. Platelet-derived growth factor induces tissue factor expression in vascular smooth muscle cells via activation of Egr Basic Res Cardiol. Tissue factor expression in human arterial smooth muscle cells.
TF is present in three cellular pools after growth factor stimulation. Vascular endothelial growth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: conversion of prothrombin to thrombin results in progelatinase A activation and cell proliferation.
Platelet-derived TGF-beta induces tissue factor expression via the Smad3 pathway in osteosarcoma cells. J Bone Miner Res. Tissue factor as a link between inflammation and coagulation. Procoagulant and proinflammatory effects of red blood cells on lipopolysaccharide-stimulated monocytes. Interferon-gamma and tumor necrosis factor-alpha act synergistically to up-regulate tissue factor in alveolar epithelial cells. Exp Lung Res. Histamine induces tissue factor expression: implications for acute coronary syndromes.
Effect of human recombinant interleukin-6 and interleukin-8 on monocyte procoagulant activity. Expression of tissue factor and interleukin-1 beta in a novel rabbit model of disseminated intravascular coagulation induced by carrageenan and lipopolysaccharide. Interleukin-1beta induced vascular permeability is dependent on induction of endothelial tissue factor TF activity.
J Transl Med. Tissue factor is induced by interleukin in human endothelial cells: a new link between coagulation and inflammation. CD40 ligation induces tissue factor expression in human vascular smooth muscle cells. Activated protein C up-regulates IL and inhibits tissue factor in blood monocytes.
Journal of immunology Baltimore, Md : Th1 and Th2 T-helper cells exert opposite regulatory effects on procoagulant activity and tissue factor production by human monocytes. Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. Mutations of p53 and K-ras correlate TF expression in human colorectal carcinomas: TF downregulation as a marker of poor prognosis. Int J Colorectal Dis.
Oncogenic epidermal growth factor receptor up-regulates multiple elements of the tissue factor signaling pathway in human glioma cells. Cancer research. Tissue factor regulation by epidermal growth factor receptor and epithelial-to-mesenchymal transitions: effect on tumor initiation and angiogenesis. PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma. Regulation of tissue factor expression by anti-oncogene PTEN in human neuroblastoma cell line.
Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN. Clin Chem. Tissue factor expression predicts outcome in children with neuroblastoma: a retrospective study.
Oncology letters. Early growth response gene-1 and hypoxia-inducible factor-1alpha affect tumor metastasis via regulation of tissue factor. Acta Oncol. Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells.
Oncology reports. Hypoxia regulates the expression of tissue factor pathway signaling elements in a rat glioma model. Methylation-dependent tissue factor suppression contributes to the reduced malignancy of IDH1 mutant gliomas.
Clin Cancer Res. Mutant IDH1 and thrombosis in gliomas. Acta Neuropathol. Liu Y, Mueller BM. Tissue factor regulates tumor angiogenesis of retinoblastoma via the extracellular signal-regulated kinase pathway.
Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development. Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor.
CAS Google Scholar. Evidence for tissue factor phosphorylation and its correlation with protease-activated receptor expression and the prognosis of primary breast cancer. Role of tissue factor in embryonic blood vessel development. Vasculogenesis and angiogenesis in VEGF receptor-1 deficient mice. Methods in molecular biology Clifton, NJ.
Tissue factor expression and angiogenesis in human glioma. Clin Biochem. Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer. Tissue factor expression and angiogenesis in human prostate carcinoma.
There is some controversy about the importance of live or killed bacteria in tissue factor induction 45, Recently, it was demonstrated that the cell wall peptidoglycan of S. The kinetics of tissue factor induction by LPS and peptidoglycan is similar, with maximal procoagulant activity developing within 4 h. However, LPS is a fold more potent stimulus of tissue factor expression compared to peptidoglycan Although S.
With these organisms, it is hypothesized that the formation of the vegetation is induced by tissue factor expressed by monocytes, rather than the endothelial cells.
Aspergillus fumigatus is an angioinvasive fungus, and invasive aspergillosis is characterized by vascular invasion with subsequent thrombosis and tissue infarction We have developed an in vitro model of interaction of A.
Our data indicate that A. Candida albicans is another angioinvasive fungus. However, vascular thrombosis is not usually seen at foci of candidal infection. Interestingly, we found that C. Similarly, in a patient with candidemia, it was found that the monocytes did not express tissue factor. In contrast, monocytes from patients with systemic bacterial infections strongly expressed tissue factor These observations suggest that tissue factor expression is tightly controlled and is induced only in response to specific microbial pathogens.
In conclusion, activation of endothelial cell tissue factor-mediated procoagulant activity is a key event in the pathogenesis of several types of infection. Understanding this process and developing methods to control it hold great promise for improving the outcome of these severe and often fatal infections. Address for correspondence: L. E-mail: leila uerj. Received January 14, Accepted March 26, Abrir menu Brasil. Brazilian Journal of Medical and Biological Research.
Abrir menu. Lopes-Bezerra S. Filler About the authors. Tissue factor; Endothelial cell; Fungus; Infectious diseases; Procoagulant activity. Lopes-Bezerra 1 and S. Selective cellular expression of tissue factor in human tissues.
Implications for disorders of hemostasis and thrombosis. American Journal of Pathology , Localization of tissue factor in the normal vessel wall and in atherosclerotic plaque. Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody.
Thrombosis Research , Morrissey JH Tissue factor: an enzyme cofactor and a true receptor. Thrombosis and Haemostasis , Endothelial cell dysfunction and coagulation. Evolving role of tissue factor and its pathway inhibitor. Journal of Biological Chemistry , Signal transduction via the mitogen-activated protein kinase pathway induced by binding of coagulation factor VIIa to tissue factor.
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Thus, TF interaction with other coagulation factors, mainly factor VII, activates the extrinsic coagulation pathway finally leading to the acute formation of intravascular thrombus 8. In the last two decades, our knowledge of TF biology is significantly changed 9. Specifically, in the context of coagulation, the discovery of a circulating TF pool, in which TF may be found as soluble form 10 , 11 , bound to MPs 12 , 13 or blood cells-derived 14 - 18 has modified the old biological dogma of TF localized in the vessel-wall under the endothelial layer Moreover, many studies have clearly indicated that TF, beyond the primary role as initiator of the coagulation cascade, is actively involved in other biological phenomena not related with coagulation.
Indeed, it has been demonstrated that TF modulates signaling transduction, apoptosis 20 , gene and protein expression 21 , cell proliferation 22 , angiogenesis 23 , 24 , and tumor metastasis 23 , This review, starting from the old point of view about TF as initiator of extrinsic coagulation pathway, briefly illustrates the more recent concepts about TF and thrombosis and finally gives an overview about its role beyond thrombosis and haemostasis focusing on the different intracellular mechanisms triggered by its activation and potentially involved in atherosclerosis.
It belongs to the class 2 cytokine receptor superfamily The mature protein includes amino acids in a single polypeptide chain The membrane anchoring peptide includes amino acids while the intracellular C-terminus domain consists of amino acids In this complex, the activity of FVII is enhanced of several fold due to the rearrangements of the active site region In the absence of PL, the rate of activation is slow 34 , As final step, thrombin FIIa is generated at the site of vessel injury thus, leading to platelet activation and aggregation, fibrin production and ultimately intravascular thrombus formation as shown in Figure 1 1.
Biochemically, FXa seems to be at a critical point of the coagulation process because it receives the upstream extrinsic and intrinsic signals and dictates the downstream coagulation. For these reasons, in the last decade several pharmacological strategies have been developed to modulate its function in the coagulation cascade In , Giesen et al. This initial observation was confirmed by many other reports; thus it is now largely accepted that TF circulates in the flowing blood at least in three different pools: as white cells and platelets-associated 16 , 39 ; as cell-derived MPs 13 ; and as a soluble protein namely alternative splicing TF or asTF Monocytes are one of the major source s of TF 39 , 40 , involved in thrombus formation in patients with myocardial infarction 41 , 42 as well as in other thrombotic disorders Although TF synthesis and expression by platelets has been matter of debate 43 , 44 , in vitro generation of platelet-like particles from differentiated human megakaryocytes showed that platelets can carry both TF protein and mRNA 45 and platelet activation can induce maturation of this TF mRNA, protein translation and surface translocation TF is also expressed by neutrophils triggering thrombin generation and thrombus formation Activation of neutrophils is required for TF exposure on the cell membrane Platelets 16 , neutrophils 48 and, as reported more recently, even T-lymphocytes 17 may be an important source of TF in patients presenting with ACS.
Human eosinophils can carry TF in intracellular granules Upon stimulation with platelet-activating factor PAF or granulocyte macrophage colony-stimulating factor, TF is translocated to cell surface, where it can trigger coagulation and supports trans endothelial migration
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